Preclinical Imaging

Kurt Zinn, D.V.M, Ph.D.
– Director

Hyunki Kim, Ph.D.
– Assistant Director

Contact: (205) 975-6414



The goal of the Preclinical Imaging Shared Facility (PCISF) is to support multimodality imaging in appropriate preclinical models. Our overall mission is to accelerate the translation of basic research to human trials that will ultimately benefit patients. Imaging conducted in the facility currently provides rapid, repeated, accurate, and cost-effective evaluation of new cancer treatments in preclinical models, using the most sophisticated technologies available.  The facility has undertaken a multimodality imaging approach to provide a molecular understanding of cancer in animal models by integrating measurements of tumor mass, tumor receptors, tumor-specific targeting, vascular parameters, and specific therapy responses.  Importantly, many of the technologies applied in the preclinical context are similarly applied in UAB-CCC clinical trials.  The specific aims of the Preclinical Imaging Shared Facility are as follows:

  1. To provide state-of-the-art molecular imaging for preclinical studies in appropriate animal models, and support IND’s for transition to human imaging studies.
  2. To provide consultation and training to UAB-CCC members for molecular imaging in cancer models.
  3. To establish methods for image analyses.
  4. To maintain the instruments and keep them accurately calibrated.
  5. To develop novel imaging technologies and acquire new instruments

During the current funding period (2011-2014) a total of 54 UAB-CCC investigators were supported, of which 36 investigators had one or more NCI grants (Table 1. Research Strategy Section D).  There were 92 total users, therefore, 38 users that were not UAB-CCC investigators.  Major facility upgrades, equipment purchases, technology development, and faculty hiring during the current funding period have positioned our Shared Resource to more significantly support UAB-CCC investigators in their preclinical research studies.

Contact Information:

Director: Kurt Zinn, D.V.M., Ph.D.
Phone: (205) 975-6414

Assistant Director: Hyunki Kim, Ph.D.
Phone: (205) 996-4088

Co-Investigator: Ken Hoyt, Ph.D.
Phone: (205) 934-3116

Co-Investigator: Michael Azure, Ph.D.
Phone: (205) 975-6467

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