The University of Alabama at Birmingham (UAB) Comprehensive Cancer Center was designated one of the first 11 “comprehensive” cancer centers in 1972. Today, the UAB Comprehensive Cancer Center is the only National Cancer Institute (NCI)-designated cancer center in a five-state region: Alabama, Arkansas, Georgia, Louisiana and Mississippi. The Center, which emphasizes multidisciplinary research and patient care, has grown to more than 350 faculty members (including basic and clinical scientists and physicians). It encompasses more than 150,000 square feet of research space and has more than $100 million in annual research funding. Faculty expertise includes tumor biology, virology/gene therapy, immunobiology, targeted immunotherapy, drug discovery and experimental therapeutics. Cancer Center Director Edward Partridge, M.D., is a nationally recognized expert in the fields of women’s cancers and outreach among minorities and underserved populations, an area in which UAB is particularly well-regarded. The Center has also made obesity and its impact on cancer a high-priority research focus going forward. UAB is the recipient of three NCI SPORE (Specialized Program of Research Excellence) grants: breast, brain tumor and pancreatic cancer.