BIOLOGICAL SCIENCE is a process of

never-ending discovery that seems to lead to

ever-increasing complexity. Applications of the

technological advances of the last decade have

unleashed a tsunami of information, which will

require a systematic approach to understand-

ing and teasing out the key elements that can

inform us regarding cancer development and

progression.

To that end, National Cancer Institute-

designated comprehensive cancer centers such

as ours, charged with advancing the world’s

understanding of cancer, must continue to cre-

atively build transdisciplinary teams of scientists.

These teams will need to systematically examine

the impact of genetic and epigenetic factors,

signaling pathways, cells, organs, individual behav-

iors, family, community, environment and policy

on the development and progress of diseases

such as cancer.

In this issue of UAB Comprehensive Cancer

Center magazine, you will read about the

Alabama Drug Discovery Alliance and how

the UAB Comprehensive Cancer Center is

integrated into this program and how teams of

scientists with different expertise can acceler-

ate drug development. You also will learn about

our partnership with HudsonAlpha Institute for

Biotechnology and how this adds to our under-

standing of the

genetic basis for

disease. You also

will read about

informatics—the

term given to

the assimilation

and understand-

ing of the key

elements of the

tremendous

amount of infor-

mation acquired by a systematic approach—and

how our programs in this area are critical to our

knowledge development.

In addition, we profile two of our senior lead-

ers—Richard Whitley, M.D., associate director

of drug discovery and development, and Etty

“Tika” Benveniste, Ph.D., associate director for

basic research.

We hope you enjoy this issue and that it gives

you some sense of what the next generation

of cancer research will look like—and how the

UAB Comprehensive Cancer Center will be

leading the way.

Edward Partridge, M.D. Director and Evalina B. Spencer Chair in Oncology

lnews from the director

For a free subscription to UAB

Comprehensive Cancer Center, please call

(205) 934-0321 or send an e-mail with your

name and address to info@ccc.uab.edu.

2011 • VOLU ME XXVII •

NUMBER 1

AN NCI-DES IGNATED C

OMPREHEN SIVE

CANCER CE NTER SINCE

1971

of Progress an d Promise

2011 • VOLUME XXVII • NUMBER 2

AN NCI-DESIGNATED COMPREHENSIVE CANCER CENTER SINCE 1971

COMPREHENSIVE CANCER CENTER

THE IMPACT OF OBESITY ON CANCER

UAB COMPREHENSIVE CANCER CENTER

Director Edward E. Partridge, M.D.

Associate Directors Etty Benveniste, Ph.D. Mary-Ann Bjornsti, Ph.D. Wendy Demark-Wahnefried, Ph.D., R.D. John Fiveash, M.D. Martin Heslin, M.D. Mansoor Saleh, M.D. Richard Whitley, M.D.

Director Emeritus and Advisor to the Director Albert F. LoBuglio, M.D.

Senior Advisors Kirby I. Bland, M.D. James Bonner, M.D.

Associate Director for Administration Michael Bertram, Ph.D., M.B.A.

OFFICE OF DEVELOPMENT AND COMMUNITY RELATIONS

Director of Education and Supportive Services Teri Hoenemeyer, M.S.H.A.

Editor, Communications and Publications Josh Till

Manager, Special Events and Board Relations Miranda Wesley

Media Relations Specialist Beena Thannickal

Program Administrator, Gifts Katy Smith

Program Manager, Volunteer Relations Callie Dunaway

UAB COMPREHENSIVE CANCER CENTER MAGAZINE

Editor Josh Till

Medical Advisor Edward E. Partridge, M.D.

Project Manager Caperton Gillett

Writers Sara Brandon Christy McKenzie Beena Thannickal Josh Till Heather Watts

Art Directors Ron Gamble Jessica Huffstutler

Copy Editors Caperton Gillett Josh Till

Photographers Josh Till Steve Wood

Production Traci Bratton

Printing UAB Print Plant

Produced by the Office of Development and Community Relations in collaboration with the UAB Periodicals Group.

Stay connected to our progress in the fight against cancer at Dr. Partridge’s blog— your direct line to one of the nation’s leading cancer experts. uabccc.blogspot.com

The Director’s Line