u A b C o m P r e H e N S I V e C A N C e r C e N T e r 15

other therapies to treat pancreatic cancer.

Project leaders are Dr. Buchsbaum and

Albert LoBuglio, M.D., director emeritus of

the UAB Comprehensive Cancer Center.

• Genomic analysis of cancer regulators.

Investigators will perform an in-depth

genetic analysis of pancreatic cancer cells

to help unravel the biological changes that

lead to tumor growth, metastasis and treat-

ment resistance. This genomic data will be

used to design new clinical trials that target

the specific genes and cellular pathways that

regulate cancer growth. Project leaders are

David Largaespada, Ph.D., of the University

of Minnesota in Minneapolis; David

Tuveson, M.D., Ph.D., of the University

of Cambridge; and Christine Iacobuzio-

Donahue, M.D., Ph.D., of Johns hopkins

University in Baltimore.

• Targeting pancreatic cancer stem cells.

Testing continues on experimental agents

that can regulate a small subset of pancre-

atic cancer cells called stem cells, which

are believed to be linked to many cases of

inoperable metastatic pancreatic cancer. One

promising agent is a genetically altered virus,

called an adenovirus, designed to attack

cancer stem cells while leaving healthy cells

untouched. Project leaders are David Curiel,

M.D., Ph.D., of Washington University in

St. Louis, and Masato yamamoto, M.D.,

Ph.D., of the University of Minnesota in


In addition to these research projects, the

SPORe grant supports a pancreatic cancer

tissue resource center, a clinical core and a

biostatistics program.

“We are extremely proud that the NCI has

awarded us this prestigious grant, making us

one of the very few elite centers to have multi-

ple SPORes,” Dr. Partridge says. “It reaffirms

our status as a leader in conducting cutting-

edge research and translating that into treat-

ments for patients. That’s the ultimate goal.”

l research update

Another Broken egg café Avo B&A Warehouse the Baskits Bellinis ristorante & Bar Big Blue Bagel Bongiorno italian restaurant Bottega restaurant Brannon’s: A Public house the Bright Star Bruster’s real ice cream café Lazio cantina! chappy’s deli chez Fonfon crape myrtle’s café crestline Bagel company crestline Seafood company culinard café demetri’s BBQ devinci’s of homewood

donut Joe’s dram edgar’s Bakery Famous Fred’s Fire the Fish market Flying Spoon at embassy Suites Frankie’s market café Fultondale Bakery gilchrist Soda Fountain hamburger heaven highlands Bar and grill homewood gourmet hot and hot Fish club icing on the cake indie candy irondale café iz café iz too Jim ‘N Nick’s Bar-B-Q Joe muggs

mAFiAozA’s margarita grill Nabeel’s Nothing but Noodles o’carrs downtown open door café Pastry Art Bake Shoppe Petruccelli’s italian eatery ragtime café rojo Silvertron café Sol y Luna ted’s restaurant trattoria centrale

urban Standard v. richards market Whataburger yogurt mountain

In November, more than 75 restaurants, cafés and eateries across Birmingham participated in the second annual Sweet on a Cure campaign. For one week, each

restaurant donated 100 percent of the proceeds from a specific dessert to the cancer

center for research.

the event was once again a tremendous success, generating significant coverage about the

work being done at the cancer center and raising $15,000.

2010 Participating restaurants


CoUrage ComPanions One-on-one emotional support

for patients and caregivers

(205) 996-5364

Brain BUDDies For patients with malignant brain

tumors and their families

Cathie robinson (205) 934-2921

new Beginnings For newly diagnosed breast cancer patients

(205) 801-8266 or 1 (800) 333-6543

Us Too Prostate cancer support group

for men and their families

John David Farris (205) 326-9439

orTHoPeDiC onCology sUPPorT groUP

michelle gray (205) 930-8564

CansUrvive gyn CanCer sUPPorT groUP

For ovarian, cervical and

endometrial cancer patients

margaret Keeton (205) 930-8676

leUKemia anD lymPHoma soCieTy PaTienT anD Family

sUPPorT groUP alma Del grosso (205) 934-0337

grieF sUPPorT groUP For anyone who has lost a loved one

Jim elrod (205) 682-9441

raDiaTion onCology sUPPorT groUP

Karen shrout (205) 975-5628

yoUng BreasT CanCer sUrvivors

sUPPorT groUP For those diagnosed before the age of 45

Hillary Parmer (205) 930-8870

members of the pancreatic SPore team (left to right) Patsy oliver, Kyoko Kojima and Senait Asmellash (front);

James mobley, William Grizzle, mike ludwig, Donald buchsbaum, Carolyn maddox, Christopher Klug and

Stacey branham (back)

18 u A b C o m P r e H e N S I V e C A N C e r C e N T e r



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