Self-Collection and HPV Testing in Unscreened Women: A Feasibility Study in Brazil

brazil-2017Principal Investigators: Isabel C. Scarinci, Ph.D., M.P.H., & Edward Partridge, M.D. – University of Alabama at Birmingham (U.S.)

Investigators: Marcia Consolaro, Ph.D., Vania Sella, Ph.D., Sandra Pelloso, Ph.D. – Universidade Estadual de Maringá (Brazil); Nadia Kienen, Ph.D. – Universidade Estadual de Londrina (Brazil); Phillip Castle, Ph.D. – Albert Einstein College of Medicine (U.S.)

Sponsors: National Cancer Institute (Supplement to P30CA013148) and Brazilian Health Ministry – Conselho Nacional de Pesquisa (CNPq)

Location: Brazil

Our long-term goal is to decrease cervical cancer incidence and mortality among women in low- and middle-income countries (LMICs) by using the most efficacious and acceptable screening method, particularly among women who do not come to the clinic for their regular Pap testing.  The purpose of this feasibility study is to compare three cervical cancer screening modalities (self-collection and HPV testing, Pap testing at the public health clinic, and choice between self-collection and HPV testing and Pap testing) among women who have not undergone cervical cancer screening within the past four years using a theory-based, culturally relevant intervention implemented by Community Health Workers (CHWs) via door-to-door visits. Three Basic Health Units (BHUs) within the public health system will be randomly assigned to one of the three screening modalities/conditions. CHWs will invite women who report not having been screened for cervical cancer in the past four years to participate in the study, and deliver a brief educational/behavioral session on cervical cancer and screening using a door-to-door approach under of one of the three conditions. The primary outcome will be adherence to cervical cancer screening.  We hypothesize that (1) Women in the “choice” and “self-collection” groups will be more likely to engage in cervical cancer screening and display higher satisfaction with their screening than women assigned to the “Pap” with women assigned to the “choice” group having the highest adherence of the three groups; and (2) Within the “choice” group, more women will choose and complete self-collection than Pap test.

 

The specific aims are:

  1. To conduct a formative evaluation phase to adapt a theory-based, culturally relevant CHW intervention to promote cervical cancer screening among un/under-screened Brazilian women;
  2. To examine the feasibility of three cervical cancer screening modalities (self-collection and HPV testing, Pap testing at the local public health clinic, and choice between self-collection and HPV testing and Pap testing) among women who have not undergone cervical cancer screening within the past four years through the intervention developed under Specific Aim 1;
  3. To promote team science through formal and informal exchanges of experiences and expertise.